Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function
Masud, Ali J.; Kastaniotis, Alexander J.; Rahman, M. Tanvir; Autio, Kaija J.; Hiltunen, J. Kalervo (2019-08-29)
Ali J. Masud, Alexander J. Kastaniotis, M. Tanvir Rahman, Kaija J. Autio, J. Kalervo Hiltunen, Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1866, Issue 12, 2019, 118540, ISSN 0167-4889, https://doi.org/10.1016/j.bbamcr.2019.118540
© 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license by http://creativecommons.org/licenses/by-nc-nd/4.0/.
https://creativecommons.org/licenses/by-nc-nd/4.0/
https://urn.fi/URN:NBN:fi-fe202103046511
Tiivistelmä
Abstract
Acyl carrier protein (ACP) is a principal partner in the cytosolic and mitochondrial fatty acid synthesis (FAS) pathways. The active form holo-ACP serves as FAS platform, using its 4′-phosphopantetheine group to present covalently attached FAS intermediates to the enzymes responsible for the acyl chain elongation process. Mitochondrial unacylated holo-ACP is a component of mammalian mitoribosomes, and acylated ACP species participate as interaction partners in several ACP-LYRM (leucine-tyrosine-arginine motif)-protein heterodimers that act either as assembly factors or subunits of the electron transport chain and Fe-S cluster assembly complexes. Moreover, octanoyl-ACP provides the C8 backbone for endogenous lipoic acid synthesis. Accumulating evidence suggests that mtFAS-generated acyl-ACPs act as signaling molecules in an intramitochondrial metabolic state sensing circuit, coordinating mitochondrial acetyl-CoA levels with mitochondrial respiration, Fe-S cluster biogenesis and protein lipoylation.
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