Histological characteristics of early‐stage oral tongue cancer in young versus older patients : a multicenter matched‐pair analysis
Bello, Ibrahim O.; Almangush, Alhadi; Heikkinen, Ilkka; Haglund, Caj; Coletta, Ricardo D.; Kowalski, Luiz P.; Mäkitie, Antti A.; Nieminen, Pentti; Leivo, Ilmo; Salo, Tuula (2020-01-29)
Bello, IO, Almangush, A, Heikkinen, I, et al. Histological characteristics of early‐stage oral tongue cancer in young versus older patients: A multicenter matched‐pair analysis. Oral Dis. 2020; 26: 1081– 1085. https://doi.org/10.1111/odi.13288
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved. This is the peer reviewed version of the following article: Bello, IO, Almangush, A, Heikkinen, I, et al. Histological characteristics of early‐stage oral tongue cancer in young versus older patients: A multicenter matched‐pair analysis. Oral Dis. 2020; 00: 1– 5, which has been published in final form at https://doi.org/10.1111/odi.13288. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
https://rightsstatements.org/vocab/InC/1.0/
https://urn.fi/URN:NBN:fi-fe2020061042593
Tiivistelmä
Abstract
Little is known about the histopathological characteristics that may differentiate early oral tongue cancer (OTSCC) between young and older patients. From a total of 311 cases diagnosed with clinically early‐stage OTSCC at 6 institutions, only 42 patients were young patients were aged ≤45 years. For comparison, 42 patients >60 years old were matched for center of management, clinical stage and gender. We compared epithelial and stromal histopathologic parameters between the two groups. Most of the parameters were similar between the two groups, although the young patients appeared to have marginally higher intensity of tumor budding, histologic risk score, infiltrative pattern of invasion and tumor‐stroma ratio. However, none of the factors showed significant difference when comparing the two groups. The histological parameters reflect mechanisms of invasive growth and tissue response to invasive growth, but not the etiological difference in OTSCC between young and older patients. Further investigations are necessary to compare the genetic background of early OTSCC in the two groups.
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