Brain metabolism changes in cases of impaired breathing or blood circulation in rodents evaluated by real time optical spectroscopy methods
Piavchenko, Gennadii A.; Seryogina, Evgeniya S.; Kandurova, Ksenia Yu.; Shupletsov, Valery V.; Kozlov, Igor O.; Stavtsev, Dmitry D.; Stelmashchuk, Olga A.; Zherebtsov, Evgeny A.; Dremin, Viktor V.; Alekseyev, Aleksander G.; Kuznetsov, Sergey L.; Dunaev, Andrey V.; Meglinski, Igor V. (2020-02-21)
Gennadii A. Piavchenko, Evgeniya S. Seryogina, Ksenia Yu. Kandurova, Valery V. Shupletsov, Igor O. Kozlov, Dmitry D. Stavtsev, Olga A. Stelmashchuk, Evgeny A. Zherebtsov, Viktor V. Dremin, Aleksander G. Alekseyev M.D., Sergey L. Kuznetsov M.D., Andrey V. Dunaev, and Igor V. Meglinski "Brain metabolism changes in cases of impaired breathing or blood circulation in rodents evaluated by real time optical spectroscopy methods", Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112341E (21 February 2020); https://doi.org/10.1117/12.2545708
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https://urn.fi/URN:NBN:fi-fe2020111089856
Tiivistelmä
Abstract
The aim of the study was to compare the metabolic activity of brain cortex after the acute hypoxia caused by the impairment of breathing or blood circulation. Male Wistar rats were randomized in two groups: impaired breathing and blood circulation failure groups. Fluorescence under 365 and 450 nm excitation and diffuse reflectance intensity at 550–820 nm range were estimated. We found that after long-term hypoxic conditions, notable metabolic changes occur. We suppose that oxygen deficiency causes an activation of the GABA shunt mechanism. In cases of blood circulation failure, fluorescence intensity changes faster than in cases of breathing impairment.
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