Association between homocysteine, vitamin B₁₂, folic acid and erectile dysfunction : a cross-sectional study in China
Chen, Yang; Li, Jie; Li, Tianyu; Long, Jianxiong; Liao, Jinling; Wei, Gong-Hong; Mo, Zengnan; Cheng, Jiwen (2019-05-22)
Chen Y, Li J, Li T, et al. Association between homocysteine, vitamin B₁₂, folic acid and erectile dysfunction: a cross-sectional study in China, BMJ Open 2019;9:e023003. doi: 10.1136/bmjopen-2018-023003
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
https://creativecommons.org/licenses/by-nc/4.0/
https://urn.fi/URN:NBN:fi-fe2020041618859
Tiivistelmä
Abstract
Objectives: Erectile dysfunction (ED) affects up to 53.4% of men aged 30–80 years. In this study, we aimed to examine the association between homocysteine (HCY), vitamin B₁₂ (B12), folic acid (FA) and ED.
Design: Cross-sectional study.
Setting: Guangxi, China.
Participants: A total of 1381 participants who completed questionnaires were included, between September 2009 and December 2009.
Measures: ED was evaluated by the International Index of Erectile Function scores. Also, the values of HCY, B12 and FA were acquired. Then, regression and between-group analyses were performed.
Results: No association between FA and ED was found. Significant correlations between HCY and ED were found—the relationships between these two parameters were most notable in men aged over 60 years and in men living alone (bachelors or bachelorhood). B12 levels were higher in men with ED (718.53±234.37 pg/mL vs 688.74±229.68, p=0.015). Using multinomial logistic regression analyses, B12 levels were related to mild ED (multivariate adjusted analysis: OR 1.620, 95% CI 1.141 to 2.300, p=0.007), especially among men aged 40–49 years (OR 2.907, 95% CI 1.402 to 6.026, p=0.004).
Conclusions: We report, for the first time, a relationship between B12 levels and ED. We also found specific cohorts of men for whom the relationship between HCY levels and ED is most prominent. Further studies are required to elucidate the mechanisms underlying these relationships—these may ultimately result in new therapies for ED.
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