Investigation of blood microcirculation parameters in patients with rheumatic diseases by videocapillaroscopy and laser Doppler flowmetry during cold pressor test
Stavtsev, Dmitry D.; Volkov, Mikhail V.; Margaryants, Nikita B.; Potemkin, Andrey V.; Dremin, Viktor V.; Kozlov, Igor O.; Makovik, Irina N.; Zherebtsov, Evgeny A.; Dunaev, Andrey V. (2019-06-03)
Dmitry D. Stavtsev, Mikhail V. Volkov, Nikita B. Margaryants, Andrey V. Potemkin, Viktor V. Dremin, Igor O. Kozlov, Irina N. Makovik, Evgeny A. Zherebtsov, and Andrey V. Dunaev "Investigation of blood microcirculation parameters in patients with rheumatic diseases by videocapillaroscopy and laser Doppler flowmetry during cold pressor test", Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 110650T (3 June 2019); https://doi.org/10.1117/12.2523190
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Videocapillaroscopy (VCS) and laser Doppler flowmetry (LDF) are non-invasive methods for evaluating microcirculation parameters. The VCS method is based on a high-speed video recording of capillaries in the nailfold. The recorded video frames are processed using a specialized algorithm to determine the red blood cells velocity. The LDF technique is based on the analysis of the Doppler shift of back-scattered laser radiation from moving red blood cells. In this work, simultaneous measurements of VCS and LDF have been performed in healthy volunteers and rheumatic patient. The study was conducted using a cold pressor test. Changes were recorded in response to cold exposure in rheumatic diseases.
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