Biochemical changes in irradiated oral mucosa : a FTIR spectroscopic study
Ukkonen, Helena; Vuokila, Simo; Mikkonen, Jopi J. W.; Dekker, Hannah; Schulten, Engelbert A. J. M.; Bloemena, Elisabeth; Koistinen, Arto; Valdez, Tulio A.; Kullaa, Arja M.; Singh, Surya Pratap (2019-01-13)
Ukkonen, H.; Vuokila, S.; Mikkonen, J.J.W.; Dekker, H.; Schulten, E.A.J.M.; Bloemena, E.; Koistinen, A.; Valdez, T.A.; Kullaa, A.M.; Singh, S.P. Biochemical Changes in Irradiated Oral Mucosa: A FTIR Spectroscopic Study. Biosensors 2019, 9, 12. https://doi.org/10.3390/bios9010012
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2020040110056
Tiivistelmä
Abstract
Radiation exposure during the course of treatment in head and neck cancer (HNC) patients can induce both structural and biochemical anomalies. The present study is focused on utilizing infrared imaging for the identification of the minor biochemical alterations in the oral mucosa. Chemical maps generated using glycoprotein band indicates its differential distribution along the superficial layer. Spectra extracted from this layer suggests changes in overall nucleic acid and protein content in response to the therapeutic irradiation. Discrimination among control and irradiated groups have been achieved using principal component analysis. Findings of this preliminary study further support prospective utilization of Fourier Transform InfraRed (FTIR) imaging as a non-destructive, label-free tool for objective assessment of the oral mucosa in patient groups with or without radiation therapy.
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