Analysis of skin blood microflow oscillations in patients with rheumatic diseases
Mizeva, Irina; Makovik, Irina; Dunaev, Andrey; Krupatkin, Alexander; Meglinski, Igor (2017-07-13)
Irina Mizeva, Irina Makovik, Andrey Dunaev, Alexander Krupatkin, Igor Meglinski, "Analysis of skin blood microflow oscillations in patients with rheumatic diseases," Journal of Biomedical Optics 22(7), 070501 (13 July 2017). http://dx.doi.org/10.1117/1.JBO.22.7.070501
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in t his paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/1.JBO.22.7.070501
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https://urn.fi/URN:NBN:fi-fe2019082325277
Tiivistelmä
Abstract
Laser Doppler flowmetry (LDF) has been applied for the assessment of variation in blood microflows in patients with rheumatic diseases and healthy volunteers. Oscillations of peripheral blood microcirculation observed by LDF have been analyzed utilizing a wavelet transform. A higher amplitude of blood microflow oscillations has been observed in a high frequency band (over 0.1 Hz) in patients with rheumatic diseases. Oscillations in the high frequency band decreased in healthy volunteers in response to the cold pressor test, whereas lower frequency pulsations prevailed in patients with rheumatic diseases. A higher perfusion rate at normal conditions was observed in patients, and a weaker response to cold stimulation was observed in healthy volunteers. Analysis of blood microflow oscillations has a high potential for evaluation of mechanisms of blood flow regulation and diagnosis of vascular abnormalities associated with rheumatic diseases.
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