Mapping of polycrystalline films of biological fluids utilizing the Jones-matrix formalism
Ushenko, Vladimir A; Dubolazov, Alexander V; Pidkamin, Leonid Y; Sakchnovsky, Michael Yu; Bodnar, Anna B; Ushenko, Yuriy A; Ushenko, Alexander G; Bykov, Alexander; Meglinski, Igor (2018-01-08)
Vladimir A Ushenko et al 2018 Laser Phys. 28 025602. DOI: 10.1088/1555-6611/aa8cd9
© 2018 Astro Ltd. This is an author-created, un-copyedited version of an article published in Laser Physics. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1555-6611/aa8cd9.
https://rightsstatements.org/vocab/InC/1.0/
https://urn.fi/URN:NBN:fi-fe2019041011693
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Abstract
Utilizing a polarized light approach, we reconstruct the spatial distribution of birefringence and optical activity in polycrystalline films of biological fluids. The Jones-matrix formalism is used for an accessible quantitative description of these types of optical anisotropy. We demonstrate that differentiation of polycrystalline films of biological fluids can be performed based on a statistical analysis of the distribution of rotation angles and phase shifts associated with the optical activity and birefringence, respectively. Finally, practical operational characteristics, such as sensitivity, specificity and accuracy of the Jones-matrix reconstruction of optical anisotropy, were identified with special emphasis on biomedical application, specifically for differentiation of bile films taken from healthy donors and from patients with cholelithiasis.
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