Myofibroblasts in oral potentially malignant disorders : is it related to malignant transformation?
Coletta, R. D.; Salo, T. (2018-02-26)
Coletta, RD, Salo, T. Myofibroblasts in oral potentially malignant disorders: Is it related to malignant transformation?. Oral Dis. 2018; 24: 84– 88. https://doi.org/10.1111/odi.12694
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved. This is the peer reviewed version of the following article: Coletta, RD, Salo, T. Myofibroblasts in oral potentially malignant disorders: Is it related to malignant transformation?. Oral Dis. 2018; 24: 84– 88. https://doi.org/10.1111/odi.12694, which has been published in final form at https://doi.org/10.1111/odi.12694. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
https://rightsstatements.org/vocab/InC/1.0/
https://urn.fi/URN:NBN:fi-fe2019102835084
Tiivistelmä
Abstract
In oral cancer, acquisition of α‐smooth muscle actin (α‐SMA)‐positive fibroblasts, known as myofibroblasts or carcinoma‐associated fibroblasts (CAF), is an important event for progression and metastasis. However, the contribution of myofibroblasts in oral potentially malignant disorders (OPMD) remains controversial. This systematic review provides evidence that immunodetection of myofibroblasts may identify oral submucous fibrosis (OSMF) with high risk of malignant transformation, but does not represent an auxiliary tool to predict the malignant potential of leukoplakia and erythroplakia, the most common OPMD.
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