Plasma heme scavengers alpha-l-microglobulin and hemopexin as biomarkers in high-risk pregnancies
Kalapotharakos, Grigorios; Murtoniemi, Katja; Åkerström, Bo; Hämäläinen, Esa; Kajantie, Eero; Räikkönen, Katri; Villa, Pia; Laivuori, Hannele; Hansson, Stefan R. (2018-04-04)
Kalapotharakos, G., Murtoniemi, K., Åkerström, B., Hämäläinen, E., Kajantie, E., Räikkönen, K., … Hansson, S. R. (2019). Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies. Frontiers in Physiology, 10. https://doi.org/10.3389/fphys.2019.00300
© 2019 Kalapotharakos, Murtoniemi, Åkerström, Hämäläinen, Kajantie, Räikkönen, Villa, Laivuori and Hansson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2019100230813
Tiivistelmä
Abstract
Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.
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