Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults : results from a meta-analysis and exploratory meta-regression analysis
Veronese, Nicola; Cereda, Emanuele; Stubbs, Brendon; Solmi, Marco; Luchini, Claudio; Manzato, Enzo; Sergi, Giuseppe; Manu, Peter; Harris, Tamara; Fontana, Luigi; Strandberg, Timo; Amieva, Helene; Dumurgier, Julien; Elbaz, Alexis; Tzourio, Christophe; Eicholzer, Monika; Rohrmann, Sabine; Moretti, Claudio; D’Ascenzo, Fabrizio; Quadri, Giorgio; Polidoro, Alessandro; Lourenço, Roberto Alves; Moreira, Virgilio Garcia; Sanchis, Juan; Scotti, Valeria; Maggi, Stefania; Correll, Christoph U. (2017-01-28)
Nicola Veronese, Emanuele Cereda, Brendon Stubbs, Marco Solmi, Claudio Luchini, Enzo Manzato, Giuseppe Sergi, Peter Manu, Tamara Harris, Luigi Fontana, Timo Strandberg, Helene Amieva, Julien Dumurgier, Alexis Elbaz, Christophe Tzourio, Monika Eicholzer, Sabine Rohrmann, Claudio Moretti, Fabrizio D’Ascenzo, Giorgio Quadri, Alessandro Polidoro, Roberto Alves Lourenço, Virgilio Garcia Moreira, Juan Sanchis, Valeria Scotti, Stefania Maggi, Christoph U. Correll, Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis, Ageing Research Reviews, Volume 35, 2017, Pages 63-73, ISSN 1568-1637, https://doi.org/10.1016/j.arr.2017.01.003
© 2017 Elsevier B.V. Allr ights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
https://creativecommons.org/licenses/by-nc-nd/4.0/
https://urn.fi/URN:NBN:fi-fe2019091928791
Tiivistelmä
Abstract
Frailty is common and associated with poorer outcomes in the elderly, but its role as potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD. Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail/pre-frail vs. robust. The association between frailty status and CVD in cross-sectional studies was explored by calculating and pooling crude and adjusted odds ratios (ORs) ±95% confidence intervals (CIs); the data from longitudinal studies were pooled using the adjusted hazard ratios (HRs). Eighteen cohorts with a total of 31,343 participants were meta-analyzed. Using estimates from 10 cross-sectional cohorts, both frailty and pre-frailty were associated with higher odds of CVD than robust participants. Longitudinal data were obtained from 6 prospective cohort studies. After a median follow-up of 4.4 years, we identified an increased risk for faster onset of any-type CVD in the frail (HR = 1.70 [95%CI, 1.18–2.45]; I² = 66%) and pre-frail (HR = 1.23 [95%CI, 1.07–1.36]; I² = 67%) vs. robust groups. Similar results were apparent for time to CVD mortality in the frail and pre-frail groups. In conclusion, frailty and pre-frailty constitute addressable and independent risk factors for CVD in older adults.
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