Impaired glucose metabolism is associated with tooth loss in middle-aged adults : the Northern Finland Birth Cohort Study 1966
Similä, Toni; Auvinen, Juha; Puukka, Katri; Keinänen-Kiukaanniemi, Sirkka; Virtanen, Jorma I. (2018-05-30)
Toni Similä, Juha Auvinen, Katri Puukka, Sirkka Keinänen-Kiukaanniemi, Jorma I. Virtanen, Impaired glucose metabolism is associated with tooth loss in middle-aged adults: The Northern Finland Birth Cohort Study 1966, Diabetes Research and Clinical Practice, Volume 142, 2018, Pages 110-119, ISSN 0168-8227, https://doi.org/10.1016/j.diabres.2018.05.035
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Aims: We investigated the association of impaired glucose metabolism with tooth loss in adults in the Northern Finland Birth Cohort Study 1966 (NFBC1966).
Methods: We examined 4394 participants from the 46-year follow-up of the NFBC1966. Self-reported number of teeth as well as insulin and glucose values, taken during a standard oral glucose tolerance test (OGTT), served as the primary study variables. A multinomial logistic regression model served to analyse (unadjusted, smoking-adjusted and fully adjusted) the association between number of teeth (0–24, 25–27, 28–32) and glucose metabolism in women and men.
Results: Among women, type 2 diabetes — whether previously known or detected during screening — pointed to a higher likelihood of 0–24 teeth (fully adjusted OR = 2.99, 95%CI = 1.54–5.80) and 25–27 teeth (OR = 1.91, 95%CI = 1.18–3.08) than did normal glucose tolerance. Similarly, impaired fasting glucose and impaired glucose tolerance together indicated a higher likelihood of 0–24 teeth (OR = 1.71, 95%CI = 1.09–2.69) than did normal glucose tolerance. A similar, statistically non-significant, pattern emerged among men. Number of teeth associated with OGTT insulin and glucose curves as well as with the Matsuda index in both women and men.
Conclusions: Tooth loss strongly associated with impaired glucose metabolism in middle-aged Finnish women
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