Hyppää sisältöön
    • FI
    • ENG
  • FI
  • /
  • EN
OuluREPO – Oulun yliopiston julkaisuarkisto / University of Oulu repository
Näytä viite 
  •   OuluREPO etusivu
  • Oulun yliopisto
  • Avoin saatavuus
  • Näytä viite
  •   OuluREPO etusivu
  • Oulun yliopisto
  • Avoin saatavuus
  • Näytä viite
JavaScript is disabled for your browser. Some features of this site may not work without it.

Key‐genes regulating the liposecretion process of mature adipocytes

Maurizi, Giulia; Petäistö, Tiina; Maurizi, Angela; Della Guardia, Lucio (2017-09-19)

 
Avaa tiedosto
nbnfi-fe2018042418448.pdf (614.3Kt)
nbnfi-fe2018042418448_meta.xml (33.61Kt)
nbnfi-fe2018042418448_solr.xml (37.39Kt)
Lataukset: 

URL:
https://doi.org/10.1002/jcp.26188

Maurizi, Giulia
Petäistö, Tiina
Maurizi, Angela
Della Guardia, Lucio
John Wiley & Sons
19.09.2017

Maurizi, G., Petäistö, T., Maurizi, A., Della Guardia, L. (2017) Key-genes regulating the liposecretion process of mature adipocytes. Journal of Cellular Physiology, 233 (5), 3784-3793. doi:10.1002/jcp.26188

https://rightsstatements.org/vocab/InC/1.0/
© 2017 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Maurizi, G., Petäistö, T., Maurizi, A., Della Guardia, L. (2017) Key-genes regulating the liposecretion process of mature adipocytes. Journal of Cellular Physiology, 233 (5), 3784-3793. doi:10.1002/jcp.26188, which has been published in final form at https://doi.org/10.1002/jcp.26188. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
https://rightsstatements.org/vocab/InC/1.0/
doi:https://doi.org/10.1002/jcp.26188
Näytä kaikki kuvailutiedot
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi-fe2018042418448
Tiivistelmä

Abstract

White mature adipocytes (MAs) are plastic cells able to reversibly transdifferentiate toward fibroblast‐like cells maintaining stem cell gene signatures. The main morphologic aspect of this transdifferentiation process, called liposecretion, is the secretion of large lipid droplets and the development of organelles necessary for exocrine secretion. There is a considerable interest in the adipocyte plastic properties involving liposecretion process, but the molecular details are incompletely explored. This review analyzes the gene expression of MAs isolated from human subcutaneous fat tissue with respect to bone marrow (BM)‐derived mesenchymal stem cells (MSC) focusing on gene regulatory pathways involved into cellular morphology changes, cellular proliferation and transports of molecules through the membrane, suggesting potential ways to guide liposecretion. In particular, Wnt, MAPK/ERK, and AKT pathways were accurately described, studying up‐ and down‐stream molecules involved. Moreover, adipogenic extra‐ and intra‐cellular interactions were analyzed studying the role of CDH2, CDH11, ITGA5, E‐Syt1, PAI‐1, IGF1, and INHBB genes. Additionally, PLIN1 and PLIN2 could be key‐genes of liposecretion process regulating molecules transport through the membrane. All together data demonstrated that liposecretion is regulated through a complex molecular networks that are able to respond to microenvironment signals, cytokines, and growth factors. Autocrine as well as external signaling molecules might activate liposecretion affecting adipocytes physiology.

Kokoelmat
  • Avoin saatavuus [38618]
oulurepo@oulu.fiOulun yliopiston kirjastoOuluCRISLaturiMuuntaja
SaavutettavuusselosteTietosuojailmoitusYlläpidon kirjautuminen
 

Selaa kokoelmaa

NimekkeetTekijätJulkaisuajatAsiasanatUusimmatSivukartta

Omat tiedot

Kirjaudu sisäänRekisteröidy
oulurepo@oulu.fiOulun yliopiston kirjastoOuluCRISLaturiMuuntaja
SaavutettavuusselosteTietosuojailmoitusYlläpidon kirjautuminen