Probing molecular dynamics with hyperpolarized ultrafast Laplace NMR using a low-field, single-sided magnet
King, Jared N.; Fallorina, Alfredo; Yu, Justin; Zhang, Guannan; Telkki, Ville-Veikko; Hilty, Christian; Meldrum, Tyler (2018-06-28)
King, J., Fallorina, A., Yu, J., Zhang, G., Telkki, V., Hilty, C., Meldrum, T. (2018) Probing molecular dynamics with hyperpolarized ultrafast Laplace NMR using a low-field, single-sided magnet. Chemical Science, 9 (28), 6143-6149. doi:10.1039/C8SC01329B
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Laplace NMR (LNMR) offers deep insights on diffusional and rotational motion of molecules. The so-called “ultrafast” approach, based on spatial data encoding, enables one to carry out a multidimensional LNMR experiment in a single scan, providing from 10 to 1000-fold acceleration of the experiment. Here, we demonstrate the feasibility of ultrafast diffusion–T₂ relaxation correlation (D–T₂) measurements with a mobile, low-field, relatively low-cost, single-sided NMR magnet. We show that the method can probe a broad range of diffusion coefficients (at least from 10⁻⁸ to 10⁻¹² m² s⁻¹) and reveal multiple components of fluids in heterogeneous materials. The single-scan approach is demonstrably compatible with nuclear spin hyperpolarization techniques because the time-consuming hyperpolarization process does not need to be repeated. Using dynamic nuclear polarization (DNP), we improved the NMR sensitivity of water molecules by a factor of 10⁵ relative to non-hyperpolarized NMR in the 0.3 T field of the single-sided magnet. This enabled us to acquire a D–T₂ map in a single, 22 ms scan, despite the low field and relatively low mole fraction (0.003) of hyperpolarized water. Consequently, low-field, hyperpolarized ultrafast LNMR offers significant prospects for advanced, mobile, low-cost and high-sensitivity chemical and medical analysis.
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