The effect of low-dose aspirin on serum placental growth factor levels in a high-risk PREDO cohort
Murtoniemi, K.; Vahlberg, T.; Hämäläinen, E.; Kajantie, E.; Pesonen, A.K.; Räikkönen, K.; Taipale, P.; Villa, P.M.; Laivuori, H. (2018-04-07)
K. Murtoniemi, T. Vahlberg, E. Hämäläinen, E. Kajantie, A.K. Pesonen, K. Räikkönen, P. Taipale, P.M. Villa, H. Laivuori, The effect of low-dose aspirin on serum placental growth factor levels in a high-risk PREDO cohort, Pregnancy Hypertension, Volume 13, 2018, Pages 51-57, ISSN 2210-7789, https://doi.org/10.1016/j.preghy.2018.04.003
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Objectives: Our first aim was to study the longitudinal changes of serum placental growth factor (PlGF) concentration between 12+0 and 28+0 weeks of gestation in the prospective PREDO cohort. Our second aim was to study the effect of low-dose acetylsalicylic acid (LDA; 100 mg/day), started before the 14th week of gestation, on PlGF concentration.
Study design: Blood samples were collected at 12+0–14+0, 18+0–20+0 and 26+0–28+0 weeks of gestation in 101 women without and 309 with clinical risk factors for pre-eclampsia. Risk-women were divided into two groups: to those who had medium risk for pre-eclampsia and to those who had high risk for pre-eclampsia. Finally there were seven groups according to risk, treatment (no prevention/placebo/LDA) and outcome measure pre-eclampsia. Longitudinal changes in the PlGF concentration between groups were compared. To investigate the effect of LDA on serum PlGF concentration, placebo (N = 62) and LDA (N = 61) groups were compared. A repeated measures ANOVA was used to analyze differences in PlGF levels between the groups.
Results: The increase in serum PlGF concentration was higher in LDA than in placebo group (time × group effect, p = 0.046). The increase in serum PlGF concentration during pregnancy was lower in high-risk women who had placebo and developed pre-eclampsia and in medium-risk women who developed pre-eclampsia compared to the other women (time × group effect, p < 0.001). There were no differences in PlGF change between low-risk women, medium-risk women who did not develop pre-eclampsia, high-risk women in the placebo group without pre-eclampsia and high-risk women in the LDA group with and without pre-eclampsia (p = 0.15).
Conclusions: Our finding suggests an association between LDA started before 14 weeks of gestation and higher increase in serum PlGF concentration.
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