Genetic loci associated with heart rate variability and their effects on cardiac disease risk
Nolte, Ilja M.; Munoz, M. Loretto; Tragante, Vinicius; Amare, Azmeraw T.; Jansen, Rick; Vaez, Ahmad; von der Heyde, Benedikt; Avery, Christy L.; Bis, Joshua C.; Dierckx, Bram; van Dongen, Jenny; Gogarten, Stephanie M.; Goyette, Philippe; Hernesniemi, Jussi; Huikari, Ville; Hwang, Shih-Jen; Jaju, Deepali; Kerr, Kathleen F.; Kluttig, Alexander; Krijthe, Bouwe P.; Kumar, Jitender; van der Laan, Sander W.; Lyytikäinen, Leo-Pekka; Maihofer, Adam X.; Minassian, Arpi; van der Most, Peter J.; Mueller-Nurasyid, Martina; Nivard, Michel; Salvi, Erika; Stewart, James D.; Thayer, Julian F.; Verweij, Niek; Wong, Andrew; Zabaneh, Delilah; Zafarmand, Mohammad H.; Abdellaoui, Abdel; Albarwani, Sulayma; Albert, Christine; Alonso, Alvaro; Ashar, Foram; Auvinen, Juha; Axelsson, Tomas; Baker, Dewleen G.; de Bakker, Paul I. W.; Barcella, Matteo; Bayoumi, Riad; Bieringa, Rob J.; Boomsma, Dorret; Boucher, Gabrielle; Britton, Annie R.; Christophersen, Ingrid E.; Dietrich, Andrea; Ehret, George B.; Ellinor, Patrick T.; Eskola, Markku; Felix, Janine F.; Floras, John S.; Franco, Oscar H.; Friberg, Peter; Gademan, Maaike G. J.; Geyer, Mark A.; Giedraitis, Vilmantas; Hartman, Catharina A.; Hemerich, Daiane; Hofman, Albert; Hottenga, Jouke-Jan; Huikuri, Heikki; Hutri-Kähönen, Nina; Jouven, Xavier; Junttila, Juhani; Juonala, Markus; Kiviniemi, Antti M.; Kors, Jan A.; Kumari, Meena; Kuznetsova, Tatiana; Laurie, Cathy C.; Lefrandt, Joop D.; Li, Yong; Li, Yun; Liao, Duanping; Limacher, Marian C.; Lin, Henry J.; Lindgren, Cecilia M.; Lubitz, Steven A.; Mahajan, Anubha; McKnight, Barbara; zu Schwabedissen, Henriette Meyer; Milaneschi, Yuri; Mononen, Nina; Morris, Andrew P.; Nalls, Mike A.; Navis, Gerjan; Neijts, Melanie; Nikus, Kjell; North, Kari E.; O'Connor, Daniel T.; Ormel, Johan; Perz, Siegfried; Peters, Annette; Psaty, Bruce M.; Raitakari, Olli T.; Risbrough, Victoria B.; Sinner, Moritz F.; Siscovick, David; Smit, Johannes H.; Smith, Nicholas L.; Soliman, Elsayed Z.; Sotoodehnia, Nona; Staessen, Jan A.; Stein, Phyllis K.; Stilp, Adrienne M.; Stolarz-Skrzypek, Katarzyna; Strauch, Konstantin; Sundström, Johan; Swenne, Cees A.; Syvänen, Ann-Christine; Tardif, Jean-Claude; Taylor, Kent D.; Teumer, Alexander; Thornton, Timothy A.; Tinker, Lesley E.; Uitterlinden, Andre G.; van Setten, Jessica; Voss, Andreas; Waldenberger, Melanie; Wilhelmsen, Kirk C.; Willemsen, Gonneke; Wong, Quenna; Zhang, Zhu-Ming; Zonderman, Alan B.; Cusi, Daniele; Evans, Michele K.; Greiser, Halina K.; van der Harst, Pim; Hassan, Mohammad; Ingelsson, Erik; Järvelin, Marjo-Riitta; Kaab, Stefan; Kähönen, Mika; Kivimäki, Mika; Kooperberg, Charles; Kuh, Diana; Lehtimäki, Terho; Lind, Lars; Nievergelt, Caroline M.; O'Donnell, Chris J.; Oldehinkel, Albertine J.; Penninx, Brenda; Reiner, Alexander P.; Riese, Harriette; van Roon, Arie M.; Rioux, John D.; Rotter, Jerome I.; Sofer, Tamar; Stricker, Bruno H.; Tiemeier, Henning; Vrijkotte, Tanja G. M.; Asselbergs, Folkert W.; Brundel, Bianca J. J. M.; Heckbert, Susan R.; Whitsel, Eric A.; den Hoed, Marcel; Snieder, Harold; de Geus, Eco J. C. (2017-06-14)
Nolte, I., Munoz, M., Tragante, V., Amare, A., Jansen, R., Vaez, A., von der Heyde, B., Avery, C., Bis, J., Dierckx, B., van Dongen, J., Gogarten, S., Goyette, P., Hernesniemi, J., Huikari, V., Hwang, S., Jaju, D., Kerr, K., Kluttig, A., Krijthe, B., Kumar, J., van der Laan, S., Lyytikäinen, L., Maihofer, A., Minassian, A., van der Most, P., Müller-Nurasyid, M., Nivard, M., Salvi, E., Stewart, J., Thayer, J., Verweij, N., Wong, A., Zabaneh, D., Zafarmand, M., Abdellaoui, A., Albarwani, S., Albert, C., Alonso, A., Ashar, F., Auvinen, J., Axelsson, T., Baker, D., de Bakker, P., Barcella, M., Bayoumi, R., Bieringa, R., Boomsma, D., Boucher, G., Britton, A., Christophersen, I., Dietrich, A., Ehret, G., Ellinor, P., Eskola, M., Felix, J., Floras, J., Franco, O., Friberg, P., Gademan, M., Geyer, M., Giedraitis, V., Hartman, C., Hemerich, D., Hofman, A., Hottenga, J., Huikuri, H., Hutri-Kähönen, N., Jouven, X., Junttila, J., Juonala, M., Kiviniemi, A., Kors, J., Kumari, M., Kuznetsova, T., Laurie, C., Lefrandt, J., Li, Y., Li, Y., Liao, D., Limacher, M., Lin, H., Lindgren, C., Lubitz, S., Mahajan, A., McKnight, B., zu Schwabedissen, H., Milaneschi, Y., Mononen, N., Morris, A., Nalls, M., Navis, G., Neijts, M., Nikus, K., North, K., O’Connor, D., Ormel, J., Perz, S., Peters, A., Psaty, B., Raitakari, O., Risbrough, V., Sinner, M., Siscovick, D., Smit, J., Smith, N., Soliman, E., Sotoodehnia, N., Staessen, J., Stein, P., Stilp, A., Stolarz-Skrzypek, K., Strauch, K., Sundström, J., Swenne, C., Syvänen, A., Tardif, J., Taylor, K., Teumer, A., Thornton, T., Tinker, L., Uitterlinden, A., van Setten, J., Voss, A., Waldenberger, M., Wilhelmsen, K., Willemsen, G., Wong, Q., Zhang, Z., Zonderman, A., Cusi, D., Evans, M., Greiser, H., van der Harst, P., Hassan, M., Ingelsson, E., Järvelin, M., Kääb, S., Kähönen, M., Kivimaki, M., Kooperberg, C., Kuh, D., Lehtimäki, T., Lind, L., Nievergelt, C., O’Donnell, C., Oldehinkel, A., Penninx, B., Reiner, A., Riese, H., van Roon, A., Rioux, J., Rotter, J., Sofer, T., Stricker, B., Tiemeier, H., Vrijkotte, T., Asselbergs, F., Brundel, B., Heckbert, S., Whitsel, E., den Hoed, M., Snieder, H., de Geus, E. (2017) Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nature Communications, 8 (), 15805. doi:10.1038/ncomms15805
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe201708178145
Tiivistelmä
Abstract
Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74
Kokoelmat
- Avoin saatavuus [37744]
