Ultrasound assessment of human meniscus
Viren, Tuomas; Honkanen, Juuso T.; Danso, Elvis K.; Rieppo, Lassi; Korhonen, Rami K.; Töyräs, Juha (2017-06-23)
Tuomas Viren, Juuso T. Honkanen, Elvis K. Danso, Lassi Rieppo, Rami K. Korhonen, Juha Töyräs, Ultrasound Assessment of Human Meniscus, In Ultrasound in Medicine & Biology, Volume 43, Issue 9, 2017, Pages 1753-1763, ISSN 0301-5629, https://doi.org/10.1016/j.ultrasmedbio.2017.01.020. (http://www.sciencedirect.com/science/article/pii/S0301562917300492)
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
https://urn.fi/URN:NBN:fi-fe2017121155669
Tiivistelmä
Abstract
The aim of the present study was to evaluate the applicability of ultrasound imaging to quantitative assessment of human meniscus in vitro. Meniscus samples (n = 26) were harvested from 13 knee joints of non-arthritic human cadavers. Subsequently, three locations (anterior, center and posterior) from each meniscus were imaged with two ultrasound transducers (frequencies 9 and 40 MHz), and quantitative ultrasound parameters were determined. Furthermore, partial-least-squares regression analysis was applied for ultrasound signal to determine the relations between ultrasound scattering and meniscus integrity. Significant correlations between measured and predicted meniscus compositions and mechanical properties were obtained (R² = 0.38–0.69, p < 0.05). The relationship between conventional ultrasound parameters and integrity of the meniscus was weaker. To conclude, ultrasound imaging exhibited a potential for evaluation of meniscus integrity. Higher ultrasound frequency combined with multivariate analysis of ultrasound backscattering was found to be the most sensitive for evaluation of meniscus integrity.
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