Tumour budding in oral squamous cell carcinoma : a meta-analysis
Almangush, Alhadi; Pirinen, Matti; Heikkinen, Ilkka; Mäkitie, Antti A; Salo, Tuula; Leivo, Ilmo (2017-11-30)
Almangush, A., Pirinen, M., Heikkinen, I., Mäkitie, A., Salo, T., Leivo, I. (2017) Tumour budding in oral squamous cell carcinoma: a meta-analysis. British Journal of Cancer, 118, 577-586. doi:10.1038/bjc.2017.425
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Background: Tumour budding has been reported as a promising prognostic marker in many cancers. This meta-analysis assessed the prognostic value of tumour budding in oral squamous cell carcinoma (OSCC).
Results: A total of 16 studies evaluated the prognostic value of tumour budding in OSCC. The meta-analysis showed that tumour budding was significantly associated with lymph node metastasis (odds ratio=7.08, 95% CI=1.75–28.73), disease-free survival (hazard ratio=1.83, 95% CI=1.34–2.50) and overall survival (hazard ratio=1.88, 95% CI=1.25–2.82).
Conclusions: Tumour budding is a simple and reliable prognostic marker for OSCC. Evaluation of tumour budding could facilitate personalised management of OSCC.
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