Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study
Davis, James P.; Huyghe, Jeroen R.; Locke, Adam E.; Jackson, Anne U.; Sim, Xueling; Stringham, Heather M.; Teslovich, Tanya M.; Welch, Ryan P.; Fuchsberger, Christian; Narisu, Narisu; Chines, Peter S.; Kangas, Antti J.; Soininen, Pasi; Ala-Korpela, Mika; Kuusisto, Johanna; Collins, Francis S.; Laakso, Markku; Boehnke, Michael; Mohlke, Karen L. (2017-10-30)
Davis JP, Huyghe JR, Locke AE, Jackson AU, Sim X, Stringham HM, et al. (2017) Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study. PLoS Genet 13(10): e1007079. https://doi.org/10.1371/journal.pgen.1007079
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Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157 previously identified lipid loci, we identified five novel signals near established loci at HIF3A, ADAMTS3, PLTP, LCAT, and LIPG. Four of the signals were identified with a low-frequency (0.005
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