Protein kinases as switches for the function of upstream stimulatory factors : implications for tissue injury and cancer
Horbach, Tina; Götz, Claudia; Kietzmann, Thomas; Dimova, Elitsa Y. (2015-02-18)
Horbach T, Götz C, Kietzmann T and Dimova EY (2015) Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer. Front. Pharmacol. 6:3. doi: 10.3389/fphar.2015.00003
Copyright © 2015 Horbach, Götz, Kietzmann and Dimova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The upstream stimulatory factors (USFs) are regulators of important cellular processes. Both USF1 and USF2 are supposed to have major roles in metabolism, tissue protection and tumor development. However, the knowledge about the mechanisms that control the function of USFs, in particular in tissue protection and cancer, is limited. Phosphorylation is a versatile tool to regulate protein functions. Thereby, phosphorylation can positively or negatively affect different aspects of transcription factor function including protein stability, protein–protein interaction, cellular localization, or DNA binding. The present review aims to summarize the current knowledge about the regulation of USFs by direct phosphorylation and the consequences for USF functions in tissue protection and cancer.
Front. Pharmacol., 05 April 2016 | https://doi.org/10.3389/fphar.2016.00092
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