Transit of H₂O₂ across the endoplasmic reticulum membrane is not sluggish
Appenzeller-Herzog, Christian; Bánhegyi, Gabor; Bogeski, Ivan; Davies, Kelvin J.A.; Delaunay-Moisan, Agnès; Forman, Henry Jay; Görlach, Agnes; Kietzmann, Thomas; Laurindo, Francisco; Margittai, Eva; Meyer , Andreas J.; Riemer, Jan; Rützler, Michael; Simmen, Thomas; Sitia, Roberto; Toledano, Michel B.; Touw, Ivo P. (2016-02-26)
Christian Appenzeller-Herzog, Gabor Bánhegyi, Ivan Bogeski, Kelvin J.A. Davies, Agnès Delaunay-Moisan, Henry Jay Forman, Agnes Görlach, Thomas Kietzmann, Francisco Laurindo, Eva Margittai, Andreas J. Meyer, Jan Riemer, Michael Rützler, Thomas Simmen, Roberto Sitia, Michel B. Toledano, Ivo P. Touw, Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish, Free Radical Biology and Medicine, Volume 94, May 2016, Pages 157-160, ISSN 0891-5849, http://dx.doi.org/10.1016/j.freeradbiomed.2016.02.030.
© 2016 Elsevier Inc. All rights reserved.
Cellular metabolism provides various sources of hydrogen peroxide (H₂O₂) in different organelles and compartments. The suitability of H₂O₂ as an intracellular signaling molecule therefore also depends on its ability to pass cellular membranes. The propensity of the membranous boundary of the endoplasmic reticulum (ER) to let pass H₂O₂ has been discussed controversially. In this essay, we challenge the recent proposal that the ER membrane constitutes a simple barrier for H₂O₂ diffusion and support earlier data showing that (i) ample H₂O₂ permeability of the ER membrane is a prerequisite for signal transduction, (ii) aquaporin channels are crucially involved in the facilitation of H₂O₂ permeation, and (iii) a proper experimental framework not prone to artifacts is necessary to further unravel the role of H₂O₂ permeation in signal transduction and organelle biology.
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