Multi-factors including inflammatory/immune, hormones, tumor-related proteins and nutrition associated with chronic prostatitis NIH IIIa+b and IV based on FAMHES project
Chen, Yang; Li, Jie; Hu, Yanling; Zhang, Haiying; Yang, Xiaobo; Jiang, Yonghua; Yao, Ziting; Chen, Yinchun; Gao, Yong; Tan, Aihua; Liao, Ming; Lu, Zhen; Wu, Chunlei; Xian, Xiaoyin; Wei, Suchun; Zhang, Zhifu; Chen, Wei; Wei, Gong-Hong; Wang, Qiuyan; Mo, Zengnan (2017-08-22)
Chen, Y., Li, J., Hu, Y., Zhang, H., Yang, X., Jiang, Y., Yao, Z., Chen, Y., Gao, Y., Tan, A., Liao, M., Lu, Z., Wu, C., Xian, X., Wei, S., Zhang, Z., Chen, W., Wei, G., Wang, Q., Mo, Z. (2017) Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project. Scientific Reports, 7 (1), doi:10.1038/s41598-017-09751-8
© The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2017101050006
Tiivistelmä
Abstract
Chronic prostatitis (CP) is a complex disease. Fragmentary evidence suggests that factors such as infection and autoimmunity might be associated with CP. To further elucidate potential risk factors, the current study utilized the Fangchenggang Area Male Health and Examination Survey (FAMHES) project; where 22 inflammatory/immune markers, hormone markers, tumor-related proteins, and nutrition-related variables were investigated. We also performed baseline, regression, discriminant, and receiver operating characteristic (ROC) analyses. According to NIH-Chronic Prostatitis Symptom Index (NIH-CPSI), participants were divided into chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS, pain ≥ 4; divided into IIIa and IIIb sub-groups) and non-CPPS (pain = 0; divided into IV and normal sub-groups). Analyses revealed osteocalcin as a consistent protective factor for CP/CPPS, NIH-IIIb, and NIH-IV prostatitis. Further discriminant analysis revealed that ferritin (p = 0.002) and prostate-specific antigen (PSA) (p = 0.010) were significantly associated with NIH-IIIa and NIH-IV prostatitis, respectively. Moreover, ROC analysis suggested that ferritin was the most valuable independent predictor of NIH-IIIa prostatitis (AUC = 0.639, 95% CI = 0.534–0.745, p = 0.006). Together, our study revealed inflammatory/immune markers [immunoglobulin E, Complement (C3, C4), C-reactive protein, anti-streptolysin, and rheumatoid factors], hormone markers (osteocalcin, testosterone, follicle-stimulating hormone, and insulin), tumor-related proteins (carcinoembryonic and PSA), and a nutrition-related variable (ferritin) were significantly associated with CP or one of its subtypes.
Kokoelmat
- Avoin saatavuus [37957]
